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Jul 04th

Does a glass of red wine a day really keep the doctor away?

Redwine_optBY WENDY L. LEONARD

“Is drinking red wine really good for your health?”

Wow, I don’t think a week goes by without somebody asking me that question. The short answer is: Maybe.

The flurry of interest about wine consumption and health isn’t new. It really took off back in 1819, when an Irish doctor named Samuel Black made the observation that despite the French people’s high intake of saturated fats (like pork, butter and cheese), they simply weren’t dying of heart attacks and strokes at nearly the rate as people living in other countries eating similar diets (like here in America).

Dr. Black postulated that it was the French peoples’ propensity for daily wine drinking (20-30g per day) that was responsible for the counteractive effect; hence, the term, “French Paradox” – and scientists have been researching it ever since. So, what does the science say?

To begin with, there are really good, large-scale studies published in world-renowned scientific journals that strongly suggest that wine may be good for your heart. For example, there’s a study involving nearly 50,000 people (over a 10+ year period) that found that women who enjoy one glass of wine with dinner – and men who enjoy two glasses of wine with dinner – really do have a lower incidence of heart disease, heart attacks and stroke.

Another encouraging study (involving over 13,000 people over 11 years) found that men and women who drank wine in moderation were far less likely to die of heart attacks or strokes, as compared to people who didn’t drink wine. So far, so good. Let’s look at the mechanisms at work.

The apparent cause of wine’s health benefits are the anti-oxidant capabilities of the flavonoid called resveratrol in the red wine (which also gives the grapes their beautiful color) that’s responsible for imparting the protective effect. And indeed, there are lots of studies that demonstrate that resveratrol alters the coagulation system – which means it inhibits the formation of blood clots. Studies also show that resveratrol has anti-inflammatory capabilities, can lower “bad” LDL cholesterol, elevate “good” HDL cholesterol, and even helps lower blood pressure.

But, if you noticed, I began the last paragraph with the qualifier “apparent causes”. So, why the controversy? Here’s the thing: This association may be more about lifestyle than about the wine or the resveratrol. A study of 48,773 men and women found that both men and women who drink wine are also far more likely to have a higher intake of fruit and vegetables, eat more fish, and cook with olive oil – all of which we know is associated with improved heart health.

You know what else? Wine drinkers are also less likely to be smokers, have more formal education, and have the healthiest BMI scores – as opposed to those folks whose beverage of choice is beer or hard liquor. Plus, more formal education tends to result in a higher socio-economic status – which tends to afford people the ability to live in healthier surroundings, as well as enjoying better overall healthcare access. See where I’m going?

Getting back to the wine, studies also show that women who drink more than one glass of wine a day – and men who drink more than two glasses of wine a day – not only don’t get that “protective” effect of the wine, they’re also more likely to suffer from atherosclerosis (hardening of the arteries), heart disease, heart attacks and strokes. So, people’s general tendencies towards moderation – or lack thereof – may also be germane.

There’s also a really interesting six-year study (involving 12,017 women and 8,280 men) which found that the women who drank at least 5 glasses of water per day reduced their risk of dying from heart disease by 41%; and the men who drank at least 5 glasses of water each day reduced their risk by a whopping 54%.

So, is water the magic bullet? Or, is it reasonable to suggest that the type of people who choose to drink 5 glasses of water each and every day, might also choose to lead healthier lifestyles, in general? This is what I’m saying.

Which brings me back to question at hand: Is drinking red wine really good for your health?

It does seem that drinking red wine in moderation may have some real heart-healthy benefits. There’s also some very promising research about resveratrol and chemo-prevention, in terms of inhibiting tumor initiation, promotion and progression. I’ll be addressing that (and other health issues that have nothing to do with wine) in future articles.

But if you’re still wondering what I personally think about red wine … I think it’s delicious.


SOURCES
1. de Gaetano G, Di Castelnuovo A, Donati MB, Iacoviello L. The mediterranean lecture: wine and thrombosis--from epidemiology to physiology and back. Pathophysiol Haemost Thromb. Sep-2004 Dec 2003;33(5-6):466-471.
2. Hansen AS, Marckmann P, Dragsted LO, Finne Nielsen IL, Nielsen SE, Gronbaek M. Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease. Eur J Clin Nutr. Mar 2005;59(3):449-455.
3. Gronbaek M, Deis A, Sorensen TI, Becker U, Schnohr P, Jensen G. Mortality associated with moderate intakes of wine, beer, or spirits. Bmj. May 6 1995;310(6988):1165-1169.
4. Tjonneland A, Gronbaek M, Stripp C, Overvad K. Wine intake and diet in a random sample of 48763 Danish men and women. Am J Clin Nutr. Jan 1999;69(1):49-54.
5. Gall N. Is wine good for your heart? A critical review. Postgrad Med J. Mar 2001;77(905):172-176.
6. Senault C, Betoulle D, Luc G, Hauw P, Rigaud D, Fumeron F. Beneficial effects of a moderate consumption of red wine on cellular cholesterol efflux in young men. Nutr Metab Cardiovasc Dis. Apr 2000;10(2):63-69.
7. Zern TL, Fernandez ML. Cardioprotective effects of dietary polyphenols. J Nutr. Oct 2005;135(10):2291-2294.
8. Banks J, Marmot M, Oldfield Z, Smith JP. Disease and disadvantage in the United States and in England. Jama. May 3 2006;295(17):2037-2045.
9. Meier C, Ackermann-Liebrich U. [Socioeconomic class as a risk factor for cardiovascular diseases]. Ther Umsch. Sep 2005;62(9):591-595.
10. daLuz PL, Coimbra SR. Alcohol and atherosclerosis. An Acad Bras Cienc. Mar 2001;73(1):51-55.
11. Foerster M, Marques-Vidal P, Gmel G, et al. Alcohol drinking and cardiovascular risk in a population with high mean alcohol consumption. Am J Cardiol. Feb 1 2009;103(3):361-368.
12. Chan J, Knutsen SF, Blix GG, Lee JW, Fraser GE. Water, other fluids, and fatal coronary heart disease: the Adventist Health Study. Am J Epidemiol. May 1 2002;155(9):827-833.
13. Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. Jan 10 1997;275(5297):218-220.

Last Updated ( Sunday, 10 May 2009 00:59 )  
Comments (7)
7 Sunday, 03 May 2009 15:54
Nina Chazen, Personal Trainer
Being in the fietness industry, I have a peaked interest in anything having to do with healthy living. Wendy's extensive research has helped clarify the health benefits of wine drinking for both myself and my clients. I especially found the size and longevity of the studies impressive. Wendy's insights into other lifestyle factors that accompany wine drinking are thought provoking. This article has intrigued me to explore the sources sited for further information. I enjoyed this article so much that I am sending it to ALL of my clients!!!
Kudos to Wendy on a job very well done!!
6 Sunday, 03 May 2009 15:31
Nina Chazen, Personal Trainer
Being in the fitness industry, I have a peaked interest in anything having to do with healthy living. Wendy's extensive research has helped clarify the health benefits of wine drinking for both myself and my clients. I especially found the size and longevity of the studies impressive. Wendy's insight into other lifestyle factors that accompany wine drinking are thought provoking. This article has intrigued me to explore the sources sited for further information. I enjoyed this article so much that I am sending it to ALL of my clients!!!
Kudos to Wendy for a job very well done!!
5 Thursday, 30 April 2009 17:56
Dr. Dee :-)
Wendy Leonard has authored an informative and captivating article that was well researched. I think she captured the complexity of the issue; there are no simple solutions. It's true; the taste of food or drink is probably the most compelling factor to consume the item :-) Great job!
4 Wednesday, 22 April 2009 15:05
Gerald H. Fink, M.D.
Wendy Leonard has written an article on the potential benefits and dangers of drinking red wine in a most understandable and objective way.

I consider it one of the best comprehensive overviews on this controversial subject.

Kudos to Wendy Leonard
3 Saturday, 18 April 2009 16:02
Michael Grant
Clearly Wendy Leonard is a talent who knows her stuff. The research goes far beyond what might be expected for an article about drinking wine and the result is a compelling, factual piece told with a style that presents the examined truth and answers the question fairly, cleanly and concisely without the usual "dumbing down" we often encounter from lesser writers who take advanced medical theories and relay them to us poor common folk on levels that are either too dense or alarmingly simplistic. Wendy Leonard found the perfect balance and reading her piece is simultaneously illuminating and entertaining. I look forward to more!
2 Tuesday, 14 April 2009 10:57
Bo in Buffalo
In my mind, one measure of good writing is an author's ability to capture and hold a reader's attention, especially when the reader is not particularly predisposed to the most evident aspect of the book or article's content. While I prefer to enjoy grapes straight off of a vine (or grape-flavored Gatorade or Vitamin Water - sorry), the tone of the writing and the "Freakonomics"-like deeper look into the supporting data was refreshing, enlightening, and actually fun to read. Hooray for anyone who can take a relatively known topic such as this, rub it up in a fun way, and also educate so that imbibers and non-imbibers alike can retreat back to their own enjoyment levels with new-found appreciation and understanding. Can't wait for the next one - this sets a high standard, and we'll all be expecting another leap over a tall bar!........
1 Monday, 13 April 2009 11:38
Elaine Silver
This was a really clear, consise, easily understood explanation of the issues. Very well written! Thank you for publishing this. I look forward to reading more.

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