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First off, it's not a drug "ten times more powerful than vicodin". Vicodin (hydrocodone) is still the active ingredient in zohydro, but the dose will be ten times higher. I can't say for sure, but these pills will probably be 50mg extended release, as opposed to the 5mg instant release of vicodin. It should be noted, firstly, that the extended release will negate a significant portion of the drug's potency (instead of having to take a vicodin six times a day, this pill will offer an equivalent day-long pain relief from one pill) and secondly, 50mg of hydrocodone is STILL SIGNIFICANTLY WEAKER than most formulations of oxycodone prescribed in the United States. This pill is a great thing, considering that acetaminophen poisoning is the leading cause of liver failure in our country. This pill isn't more harmful, it's minimizing risks.

Moreover, I'm shocked at the amount of people who don't want this drug to see the light of day. You're forgetting that these aren't illicit drugs - they're prescribed because millions of Americans live in debilitating pain. That you people would deny 10 car accident victims or cancer patients adequate relief to stop 1 teenager from popping pills reveals that you're either shortsighted and morally bankrupt, or you have no experience with the horrors of chronic pain.

Peace.

I see that half the comments here are paid for by the drug companies. It's kinda sad, really. I'm sure someone else will "reply" to me, telling me that I'm wrong, but it'll probably Jim the Intern at Zogenix.

You'd better hurry, though, the chemists want their coffee, stat.

correct with to without

I've had neck and lower back pain for a long time-last back surgery in '05. I've tried lortabs,vicodin, oxy's, methadone,morphine all with no relief. I've never abused or taken more than perscribed. I've thought about medical marijuana. It would be nice to live pain free as it's a terrible strain on me as well as the family

oh please. addiction is none of corporate america's business. if people have the right to choose to drink alcohol and smoke tobacco, what is it about other drugs that society can't shut up about? the VAST majority of opioid-related deaths are caused in conjunction with other drugs-- mostly alcohol and acetaminophen, two of the most harmful chemicals in our country and, naturally, the most legal. hydrocodone may addict, but tylenol kills. yet no one seems to be raising any flags on that front. this new product (while certainly a ploy for more money) is going to bring a great deal of relief to a great deal of people and save a LOT of lives --even if it puts others in danger. ALL drugs carry this risk, not simply those with recreational value. how many heart medications list "death and coma" as possible side-effects? recreational drugs are not the problem. nor is addiction. addiction is a symptom of a greater, more deep-seated issue. and honestly until that problem is resolved, people are going to take drugs whatever their legality; this is 100% guaranteed. humans have been getting high for millennia, after all. spending time, money, and effort on the hype and unjustified criminalization of narcotics is an absolute waste financially, socially, and ethically. articles like this feed the media machine. it is an outdated and completely unnecessary sort of hysteria.

and if people are truly concerned about their kids hopping on the addict train i think there's a much bigger problem there than whether or not pharmaceutical companies release an addictive product and how available it is. take some responsibility and stop blaming these so-called "mystically addictive" substances for the choices people make. alternatively, suck it up, live and let live. it's none of your business.

(RE: the gun remark: yes, actually, if used properly, a gun will kill. that is its intended purpose, after all: harm. even in cases of self-defense, the keyword there is "defense". when you pick up a gun, you don't do so expecting it to fire flowers and glitter at whatever your target is. interesting that weaponry is more widely available than medication when the former is used so often to hurt OTHERS and application of the latter is a matter of personal choice.

Please remember that a painkiller is like a gun,the gun won't kill you if used properly,just like a painkiller, but the person abusing the painkiller or the person who pulls the trigger is the killer.until you live my miserable life for a month, make that a week cause you won't last, don't judge me for taking a painkiller

It is not called big business by the pharma companies. Let's lower the drinking age to 18 so the kids can drink - not drive - and not turn to their relatives meds.... CRAZY.